Tranxilium N

Tranxilium N may be available in the countries listed below.

Ingredient matches for Tranxilium N

Nordazepam

Nordazepam is reported as an ingredient of Tranxilium N in the following countries:

• Germany

International Drug Name Search

Fenigramon

Fenigramon may be available in the countries listed below.

Ingredient matches for Fenigramon

Phenytoin

Phenytoin sodium salt (a derivative of Phenytoin) is reported as an ingredient of Fenigramon in the following countries:

• Argentina

International Drug Name Search

Sunlife Calcium

Sunlife Calcium may be available in the countries listed below.

Ingredient matches for Sunlife Calcium

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Sunlife Calcium in the following countries:

• Myanmar

International Drug Name Search

Bisostad

Bisostad may be available in the countries listed below.

Ingredient matches for Bisostad

Bisoprolol

Bisoprolol fumarate (a derivative of Bisoprolol) is reported as an ingredient of Bisostad in the following countries:

• Austria


• Bulgaria


• Finland

International Drug Name Search

Simvep

Simvep may be available in the countries listed below.

Ingredient matches for Simvep

Simvastatin

Simvastatin is reported as an ingredient of Simvep in the following countries:

• Hungary

International Drug Name Search

Atomoxetine Hydrochloride

Atomoxetine Hydrochloride may be available in the countries listed below.

Ingredient matches for Atomoxetine Hydrochloride

Atomoxetine

Atomoxetine Hydrochloride (USAN) is known as Atomoxetine in the US.

International Drug Name Search

Glossary

USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Sandoz Famciclovir

Sandoz Famciclovir may be available in the countries listed below.

Ingredient matches for Sandoz Famciclovir

Famciclovir

Famciclovir is reported as an ingredient of Sandoz Famciclovir in the following countries:

• Canada

International Drug Name Search

Flubiotic

Flubiotic may be available in the countries listed below.

Ingredient matches for Flubiotic

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Flubiotic in the following countries:

• Spain

Flucloxacillin

Flucloxacillin sodium salt (a derivative of Flucloxacillin) is reported as an ingredient of Flubiotic in the following countries:

• Bangladesh

International Drug Name Search

Adco-Doxazosin

Adco-Doxazosin may be available in the countries listed below.

Ingredient matches for Adco-Doxazosin

Doxazosin

Doxazosin is reported as an ingredient of Adco-Doxazosin in the following countries:

• South Africa

International Drug Name Search

Hyaguard

Hyaguard may be available in the countries listed below.

Ingredient matches for Hyaguard

Hyaluronic Acid

Hyaluronic Acid sodium salt (a derivative of Hyaluronic Acid) is reported as an ingredient of Hyaguard in the following countries:

• Japan

International Drug Name Search

Chinina Solfato Nova Argentia

Chinina Solfato Nova Argentia may be available in the countries listed below.

Ingredient matches for Chinina Solfato Nova Argentia

Quinine

Quinine sulfate (a derivative of Quinine) is reported as an ingredient of Chinina Solfato Nova Argentia in the following countries:

• Italy

International Drug Name Search

Keflex

Keflex is a brand name of cephalexin, approved by the FDA in the following formulation(s):

KEFLEX (cephalexin - capsule; oral)

• 
  Manufacturer: SHIONOGI INC
  
  Approved Prior to Jan 1, 1982
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: SHIONOGI INC
  
  Approval date: May 12, 2006
  
  Strength(s): EQ 750MG BASE ^[RLD]

Has a generic version of Keflex been approved?

Yes. The following products are equivalent to Keflex:

cephalexin capsule; oral

• 
  Manufacturer: ALKEM
  
  Approval date: December 20, 2010
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: AUROBINDO PHARMA LTD
  
  Approval date: November 16, 2005
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: BELCHER PHARMS
  
  Approval date: July 15, 1988
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: FACTA FARMA
  
  Approved Prior to Jan 1, 1982
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: HIKMA
  
  Approval date: January 24, 2006
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: LUPIN
  
  Approval date: November 25, 2005
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: ORCHID HLTHCARE
  
  Approval date: June 28, 2005
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: RANBAXY
  
  Approval date: September 16, 1999
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: STEVENS J
  
  Approval date: March 17, 1988
  
  Strength(s): EQ 250MG BASE ^[AB]


• 
  Manufacturer: SUN PHARM INDS (IN)
  
  Approval date: June 11, 1987
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: TEVA
  
  Approval date: February 13, 1987
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]


• 
  Manufacturer: YUNG SHIN PHARM
  
  Approval date: February 24, 2005
  
  Strength(s): EQ 250MG BASE ^[AB], EQ 500MG BASE ^[AB]

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Keflex. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

There are no current U.S. patents associated with Keflex.

See also...

• Keflex Consumer Information (Drugs.com)
• Keflex Consumer Information (Wolters Kluwer)
• Keflex Suspension Consumer Information (Wolters Kluwer)
• Keflex Consumer Information (Cerner Multum)
• Keflex Advanced Consumer Information (Micromedex)
• Keflex AHFS DI Monographs (ASHP)
• Cephalexin Consumer Information (Drugs.com)
• Cephalexin Consumer Information (Wolters Kluwer)
• Cephalexin Capsules Consumer Information (Wolters Kluwer)
• Cephalexin Suspension Consumer Information (Wolters Kluwer)
• Cephalexin Consumer Information (Cerner Multum)
• Novo-Lexin Advanced Consumer Information (Micromedex)
• Panixine DisperDose Advanced Consumer Information (Micromedex)
• Cephalexin Advanced Consumer Information (Micromedex)
• Cephalexin AHFS DI Monographs (ASHP)

Benicar

In the US, Benicar (olmesartan systemic) is a member of the drug class angiotensin II inhibitors and is used to treat High Blood Pressure and Migraine Prevention.

US matches:

• Benicar


• Benicar HCT

Ingredient matches for Benicar

Olmesartan

Olmesartan Medoxomil is reported as an ingredient of Benicar in the following countries:

• Brazil


• Japan


• United States

International Drug Name Search

Flavitan

Flavitan may be available in the countries listed below.

Ingredient matches for Flavitan

Flavin Adenine Dinucleotide

Flavin Adenine Dinucleotide is reported as an ingredient of Flavitan in the following countries:

• Japan

International Drug Name Search

Calcora

Calcora may be available in the countries listed below.

Ingredient matches for Calcora

Dipyridamole

Dipyridamole is reported as an ingredient of Calcora in the following countries:

• Japan

International Drug Name Search

Captopril Aristo

Captopril Aristo may be available in the countries listed below.

Ingredient matches for Captopril Aristo

Captopril

Captopril is reported as an ingredient of Captopril Aristo in the following countries:

• Germany

International Drug Name Search

Omesar Plus

Omesar Plus may be available in the countries listed below.

Ingredient matches for Omesar Plus

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Omesar Plus in the following countries:

• Ireland


• Malta

Olmesartan

Olmesartan Medoxomil is reported as an ingredient of Omesar Plus in the following countries:

• Ireland


• Malta

International Drug Name Search

Loratadina Normon

Loratadina Normon may be available in the countries listed below.

Ingredient matches for Loratadina Normon

Loratadine

Loratadine is reported as an ingredient of Loratadina Normon in the following countries:

• Costa Rica


• Dominican Republic


• El Salvador


• Guatemala


• Honduras


• Nicaragua


• Panama


• Spain

International Drug Name Search

Rosital

Rosital may be available in the countries listed below.

Ingredient matches for Rosital

Nimodipine

Nimodipine is reported as an ingredient of Rosital in the following countries:

• Greece

International Drug Name Search

Oziclide MR

Oziclide MR may be available in the countries listed below.

Ingredient matches for Oziclide MR

Gliclazide

Gliclazide is reported as an ingredient of Oziclide MR in the following countries:

• Australia

International Drug Name Search

Heparina Winthrop

Heparina Winthrop may be available in the countries listed below.

Ingredient matches for Heparina Winthrop

Heparin

Heparin sodium salt (a derivative of Heparin) is reported as an ingredient of Heparina Winthrop in the following countries:

• Portugal

International Drug Name Search

Zonnic

Zonnic may be available in the countries listed below.

Ingredient matches for Zonnic

Nicotine

Nicotine is reported as an ingredient of Zonnic in the following countries:

• Sweden

International Drug Name Search

Dryvax

Generic Name: smallpox vaccine (Injection route)

SMAWL-pox VAX-een

Injection route(Powder for Solution)

Myocarditis, pericarditis, encephalitis, encephalomyelitis, encephalopathy, progressive vaccinia, generalized vaccinia, severe vaccinial skin infections, erythema multiforme major (including Stevens-Johnson syndrome), eczema vaccinatum resulting in permanent sequelae or death, ocular complications and blindness and fetal death, have occurred following primary vaccination or revaccination. Certain individuals are at an increased risk which may lead to severe disability, permanent neurological sequelae and/or death .

Commonly used brand name(s)

In the U.S.

• ACAM2000


• Dryvax

Available Dosage Forms:

• Powder for Suspension


• Powder for Solution

Therapeutic Class: Vaccine

Uses For Dryvax

Smallpox vaccine is an active immunizing agent used to prevent smallpox infection. It works by causing your immune system to produce its own protection (antibodies) against the virus .

This vaccine should only be administered by or under the supervision of your doctor or another health care professional .

This medicine is available only with a doctor's prescription .

Before Using Dryvax

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of smallpox vaccine in children less than 16 years of age. Safety and efficacy have not been established .

Geriatric

No information is available on the relationship of age to the effects of smallpox vaccine in geriatric patients .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aclarubicin


• Adalimumab


• Aldesleukin


• Alemtuzumab


• Altretamine


• Amonafide


• Amsacrine


• Asparaginase


• Azacitidine


• Azathioprine


• Bleomycin


• Broxuridine


• Busulfan


• Capecitabine


• Carboplatin


• Carmustine


• Certolizumab Pegol


• Chlorambucil


• Cisplatin


• Cladribine


• Cyclophosphamide


• Cytarabine


• Cytarabine Liposome


• Dacarbazine


• Dactinomycin


• Daunorubicin


• Daunorubicin Citrate Liposome


• Decitabine


• Docetaxel


• Doxifluridine


• Doxorubicin Hydrochloride


• Doxorubicin Hydrochloride Liposome


• Edatrexate


• Eflornithine


• Epirubicin


• Estramustine


• Etanercept


• Etoposide


• Everolimus


• Fingolimod


• Floxuridine


• Fludarabine


• Fluorouracil


• Fotemustine


• Gallium Nitrate


• Gemcitabine


• Golimumab


• Hydroxyurea


• Idarubicin


• Ifosfamide


• Irinotecan


• Lomustine


• Mechlorethamine


• Melphalan


• Mercaptopurine


• Methotrexate


• Mitolactol


• Mitomycin


• Mitotane


• Mitoxantrone


• Mycophenolic Acid


• Oxaliplatin


• Paclitaxel


• Pegaspargase


• Pentostatin


• Pipobroman


• Pirarubicin


• Plicamycin


• Procarbazine


• Raltitrexed


• Rilonacept


• Rituximab


• Sirolimus


• Streptozocin


• Tacrolimus


• Teceleukin


• Tegafur


• Temsirolimus


• Teniposide


• Thioguanine


• Thiotepa


• Topotecan


• Treosulfan


• Trimetrexate


• Trofosfamide


• Uracil Mustard


• Ustekinumab


• Vinblastine


• Vincristine


• Vincristine Liposome


• Vindesine


• Vinorelbine

Receiving this vaccine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abatacept


• Cytomegalovirus Immune Globulin, Human


• Hepatitis B Immune Globulin


• Immune Globulin


• Leflunomide


• Rabies Immune Globulin


• Respiratory Syncytial Virus Immune Globulin, Human


• Rho(D) Immune Globulin


• Tetanus Immune Globulin


• Vaccinia Immune Globulin, Human


• Varicella-Zoster Immune Globulin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone marrow transplant or


• Cancer or


• HIV or AIDS or


• Immune deficiency conditions or


• Leukemia (cancer of the blood) or


• Lymphoma (cancer of the lymph nodes)


• Organ transplant—Should not use in patients with these conditions .

• Burns, severe or


• Chest pain or


• Chickenpox or


• Congestive heart failure or


• Dermatitis or


• Diabetes or


• Eczema or


• Eye disease or


• Heart attack, history of or


• Heart disease (or family history of) or


• High blood pressure or


• High cholesterol in the blood or


• Impetigo or


• Psoriasis or


• Shingles or


• Stroke—May increase the chance and severity of side effects .

Proper Use of smallpox vaccine

This section provides information on the proper use of a number of products that contain smallpox vaccine. It may not be specific to Dryvax. Please read with care.

A nurse or other trained health professional will give you this vaccine. This vaccine is given by using a needle to poke or jab the skin on your upper arm .

You may need a booster dose of this vaccine every three years to maintain protection against smallpox. Ask your doctor if you will need another dose of this vaccine .

This vaccine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions .

Precautions While Using Dryvax

It is very important that your doctor check your progress at regular visits to make sure this vaccine is working properly and to check for unwanted effects .

This vaccine may cause serious heart problems in some patients. Check with your doctor right away if you are having chest pain or discomfort; dizziness; fast or irregular heartbeat; fever and chills; shortness of breath; sweating, weakness; or trouble breathing .

Tell your doctor if you smoke cigarettes or other tobacco products. The risk of heart problems is increased in people who smoke .

You should not receive this vaccine if you are using medicines that weaken your immune system, such as steroids, radiation, or cancer medicines .

You should not become pregnant for at least 3 months after receiving this vaccine without first checking with your doctor. There is a chance that this vaccine may cause problems during pregnancy. If you think you have become pregnant, tell your doctor right away .

This vaccine contains neomycin and polymyxin B. Make sure your doctor knows if you have had an allergic reaction to these medicines .

This vaccine contains a live virus. The virus can cause an infection in other parts of your body or in other people if you touch the vaccination site and then touch your body or other people. Always cover the vaccination site with a bandage. Wash your hands thoroughly after changing the bandage or after touching the vaccination site. Your doctor will tell you how to care for the vaccination site. Make sure you understand the directions and follow them carefully. Avoid contact with people who are sick or have infections until the scab falls off (usually 2 to 4 weeks after vaccination). Talk to your doctor about this if you have concerns .

You must wait at least 30 days before you can donate blood, use a hot tub or swim, handle a baby, or breastfeed .

Before you have any medical tests for syphilis or a tuberculin (TB) skin test, tell the medical doctor in charge that you have received this vaccine. The results of these tests may be affected by this vaccine .

Dryvax Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Feeling unusually cold


• shivering


• swollen, painful, or tender lymph glands in the neck, armpit, or groin

Less common

• Agitation


• anxiety


• back pain


• blindness


• blistering, peeling, or loosening of skin


• blue or pale skin


• blurred vision


• changes in vision


• chest discomfort


• chest pain, possibly moving to the left arm, neck, or shoulder


• confusion


• convulsions (seizures)


• cough


• diarrhea


• difficult or labored breathing


• dizziness


• drowsiness


• fast heartbeat


• fever and chills


• hallucinations


• headache


• irritability


• itching


• joint or muscle pain


• loss of consciousness


• mood or mental changes


• red skin lesions, often with a purple center


• red, irritated eyes


• shortness of breath


• skin rash that is encrusted, scaly, and oozing


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• stiff neck


• tightness in the chest


• trouble breathing


• unusual tiredness or weakness


• vomiting


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Decreased ability to exercise


• difficulty having a bowel movement (stool)


• difficulty with moving


• flushing or redness of the skin


• general feeling of discomfort or illness


• itching, pain, redness, or swelling at the vaccine site


• muscle aching or cramping


• muscle stiffness


• nausea


• rash


• swollen joints


• unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dryvax side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Dryvax resources

• Dryvax Side Effects (in more detail)
• Dryvax Use in Pregnancy & Breastfeeding
• Dryvax Drug Interactions
• Dryvax Support Group
• 0 Reviews for Dryvax - Add your own review/rating

• Dryvax Concise Consumer Information (Cerner Multum)


• Smallpox Vaccine Professional Patient Advice (Wolters Kluwer)

Compare Dryvax with other medications

• Smallpox Prophylaxis

Cetirizina Farmalider

Cetirizina Farmalider may be available in the countries listed below.

Ingredient matches for Cetirizina Farmalider

Cetirizine

Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Cetirizina Farmalider in the following countries:

• Spain

International Drug Name Search

Klaretop

Klaretop may be available in the countries listed below.

Ingredient matches for Klaretop

Clarithromycin

Clarithromycin is reported as an ingredient of Klaretop in the following countries:

• Greece

International Drug Name Search

Oral-B Neutra Foam

Generic Name: neutral sodium fluoride

Dosage Form: dental aerosol
Package. Label Principal Display Panel NEUTRA-FOAM
Foaming Solution

(2.0% w/w Neutral Sodium Fluoride)

FOR PROFESSIONAL USE ONLY

Active Ingredient:Sodium Fluoride 2.0% w/w (0.9% or 9048 ppm fluoride ion)
DESCRIPTION:Oral-B Neutra-Foam is a mint flavored neutral aqueous foaming solution of 2.0% w/w sodium fluoride. Inactive Ingredients:Purified water, Poloxamer 407, Isobutane, Poloxamer 234, Spearmint flavor, Potassium phosphate, Sodium saccharin, Methylparaben, Sodium hydroxide, Propylparaben. CLINICAL PHARMACOLOGY: Sodium Fluoride inhibits caries formation by reducing enamel solubility and enhancing remineralization. INDICATION AND USE:A topically applied foaming solution primarily suited for patients with extensive aesthetic restorations to aid in the prevention of dental caries. CONTRAINDICATIONS:        • Do not use in patients with hypersensitivity to fluoride.

                                            • Do not use in patients with dysphagia. WARNINGS: DO NOT SWALLOW.

• Accidental ingestion of the usual treatment dose (approximately 9.0 mg of fluoride) is not harmful. In the event more than the treatment dose is swallowed, administer calcium (e.g. milk) and get medical or contact a Poison control Center right away. One bottle of Neutra-Foam contains 1.43 grams of fluoride ion which could be lethal for children and adults.

• Keep out of the reach of infants and children under 12 years.

• Pediatric patients under 12 years of age should be supervised during use of this product.

• Avoid spraying towards open flame.

• Contents under pressure. Do not puncture or incinerate. Do not expose to heat or store at temperatures over 120°F (49°C).

PRECAUTIONS: FOR PROFESSIONAL USE ONLY.

Safety and effectiveness below age 6 have not been established. There have been no long term studies with this product to evaluate carcinogenic, mutagenic or impairment of fertility potential.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

No evidence of carcinogenicity was observed in female and male mice at doses ranging from 2.4 to 18.8 mg/kg sodium fluoride of body weight (3,4). Equivocal evidence of carcinogenicity was reported in male rats at doses ranging from 2.5 to 4.1 mg/kg fluoride, but no evidence of carcinogenicity was observed in female rats (3,4). In another study, no carcinogenicity was observed in rats treated with fluoride up to 25 mg/kg of body weight (5). Overall, epidemiological studies do not show an association between fluoridated drinking water and increased cancer risk in humans (7).

Fluoride ion is not mutagenic in standard bacterial systems but has been associated with genetic aberrations in cultured human cells at doses much higher than expected for human exposure (6,8). Some in vivo studies report chromosomal aberrations in rodents while other studies using similar protocols report negative results (7).


Potential adverse reproductive effects of fluoride exposure in humans have not been adequately evaluated. Adverse reproductive effects of fluoride have been reported in animal studies, but at high concentrations sufficient to produce other manifestations of toxicity (9).

Pregnancy:Teratogenic Effects: Pregnancy Category B. Fluoride readily crosses the placenta (7,9). Animal studies (rats and rabbits) have shown that fluoride is not a teratogen (10,12,13). Maternal exposure to 18 mg Fluoride/kg of body weight did not affect maternal body weight, litter size or fetal weight and did not increase frequency of skeletal or visceral malformations (10). There are no adequate and well-controlled studies in pregnant women. Several epidemiological studies show no increase in birth defects in areas with fluoridated water compared to areas with low fluoridated water (7). However, caution should be exercised when fluoride is administered to pregnant women. Nursing mothers: Due to the relative insensitivity of human milk fluoride levels to changes in maternal fluoride intake, and due to the very low concentrations of fluoride in human milk, fluoride supplementation during lactation would not be expected to significantly affect fluoride intake by the nursing infant (11). However, caution should be exercised when fluoride is administered to nursing women. Pediatric use: The use of fluoride solutions, gels, and foams containing up to 1.23 % fluoride ion as caries preventives in pediatric patients aged 6 to 16 years is supported by clinical studies in students aged 6 to 12 years (1,2). Safety and effectiveness in pediatric patients below the age of 6 years has not been established. Please refer to CONTRAINDICATIONS and WARNINGS sections.

Geriatric use: No overall differences in safety or effectiveness have been observed between geriatric and younger patients. This drug is known to be substantially excreted by the kidney, therefore the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

ADVERSE REACTIONS: Developing teeth of children under age 6 may become permanently discolored if excessive amounts are repeatedly swallowed. The following adverse reactions are possible in individuals hypersensitive to fluoride: eczema, atopic dermatitis, urticaria, gastric distress, headache and weakness. In patients with mucositis, gingival tissues may be hypersensitive to the flavor.

OVERDOSAGE: Accidental ingestion of large amounts of fluoride can result in acute irritation of the mouth and gastrointestinal tract as well as the development of gastrointestinal symptoms such as nausea, vomiting, diarrhea, hematemesis epigastric cramping and abdominal pain. If a large amount of fluoride equal to or greater than 5 mg fluoride/kg body weight (2.3 mg fluoride/lb body weight) is ingested, give calcium (e.g. milk, 5% calcium gluconate or calcium solution) orally to relieve gastrointestinal symptoms and admit immediately to a hospital facility. A standard treatment dose of Neutra-Foam contains approximately 9.0mg fluoride. One 165 g (5.8 oz) bottle contains approximately 1.43 g of fluoride. DOSAGE AND ADMINISTRATION: Adults and Children 6 years and over: Use foam 2 times a year. The initial time you dispense from a new bottle, gently lift upward on the nozzle to break the protective seal (thin plastic tab located adjacent to trigger). If this seal is broken do not use product. When breaking this seal, there could be an initial surge of foam from the dispenser.


• Shake bottle vigorously for 3-4 seconds prior to dispensing.

• Invert bottle 180° with nozzle tip pointed downward into tray.

• Place nozzle tip close to the tray floor and at one end of the tray arch.

Moving from one end of the tray to the other in one fluid motion, slowly press down on the trigger. (Note: foam will expand slightly to fill the tray.)

• Do not use excessive finger pressure which could result in too much foam being dispensed.

• Immediately place tray(s) in mouth. (Note: Do not fill trays with foam too far in advance of treatment as the foam will collapse and not be as effective.)

• Have patient bite down on the tray(s) lightly but firmly for up to 4 minutes.

• Remove tray(s) and have patient expectorate.

• Instruct patient not to eat, drink, or rinse for at least 30 minutes. For optimal tooth coverage, use a fluoride applicator tray which is deep enough to reach the entire vertical height of all teeth (even the molars). You can choose from single arch trays (such as CENTRAYS) or dual arch trays (CENTWINS or SOFTWINS).


HOW SUPPLIED: Neutra-Foam is available in a 5.8 oz (165 g) plastic aerosol container in mint flavor. NDC 0041-0348-06.

REFERENCES:

(1.) Wellock, W.D. and Brudevold, F.: Arch. Oral Biol., 10, 453-460 (1965) (2.) Jiang, H et al.: J. Dent, 33, 469-473 (2005) (3.) National Toxicology Program: NTP TR 393, NIH Publication 91-2842, (1990) (4.) Bucker, J.R. et al.: Int. J. Cancer 48, 733-737 (1991) (5.) Maurer, J.K. et al.: J. Natl. Cancer Inst. 82, 1118-1126 (1990) (6) Martin, G.R. et al.: Mutat. Res. 66, 159-167 (1979) (7.) Agency for Toxic Substances and Disease Registry: Toxicological Profile for Fluoride (2003)

(8.) Aardema, M.J. et al.: Mutat. Res. 331 (1), 171-172 (9.) National Research Council: Fluoride in Drinking Water (2006) (10.) Heindel, J.J. et al.: Fundam Appl Toxicol, 30, 162-177 (1996) (11.) Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes (1997) (12.) Collins, T.F. et al.: Food Chem. Toxicol. 33 (11), 951-960 (13.) Collins, T.F. et al.: Food Chem Toxicol. 39 (8), 867-876

Minute Foam Label 

ORAL-B NEUTRA-FOAM MINT  neutral sodium fluoride  aerosol

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0041-0348 Route of Administration DENTAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Sodium Fluoride (Fluoride ion) Fluoride ion 9 mg  in 1 g

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor SPEARMINT (Spearmint flavor) Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0041-0348-06 165 g In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		05/04/2000

Labeler - Oral-B Laboratories (183102243)

Revised: 10/2010Oral-B Laboratories

More Oral-B Neutra Foam resources

• Oral-B Neutra Foam Use in Pregnancy & Breastfeeding
• Oral-B Neutra Foam Support Group
• 3 Reviews for Oral-B Neutra - Add your own review/rating

Compare Oral-B Neutra Foam with other medications

• Prevention of Dental Caries

Amoxymed

Amoxymed may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Amoxymed

Amoxicillin

Amoxicillin is reported as an ingredient of Amoxymed in the following countries:

• Poland

International Drug Name Search

Sinvastatina Biolipe

Sinvastatina Biolipe may be available in the countries listed below.

Ingredient matches for Sinvastatina Biolipe

Simvastatin

Simvastatin is reported as an ingredient of Sinvastatina Biolipe in the following countries:

• Portugal

International Drug Name Search

Norfloxacina Jet

Norfloxacina Jet may be available in the countries listed below.

Ingredient matches for Norfloxacina Jet

Norfloxacin

Norfloxacin is reported as an ingredient of Norfloxacina Jet in the following countries:

• Italy

International Drug Name Search

Lomac

Lomac may be available in the countries listed below.

Ingredient matches for Lomac

Omeprazole

Omeprazole is reported as an ingredient of Lomac in the following countries:

• Czech Republic


• Ethiopia


• India


• Latvia


• Slovakia


• Vietnam

International Drug Name Search

Ketotifen CF

Ketotifen CF may be available in the countries listed below.

Ingredient matches for Ketotifen CF

Ketotifen

Ketotifen fumarate (a derivative of Ketotifen) is reported as an ingredient of Ketotifen CF in the following countries:

• Netherlands

International Drug Name Search

Differin Lotion

Pronunciation: a-DAP-a-leen
Generic Name: Adapalene
Brand Name: Differin

Differin Lotion is used for:

Treating severe acne. It may also be used for other conditions as determined by your doctor.

Differin Lotion is a retinoid-like compound. Exactly how it works is not known. However, it helps the skin cells renew quicker and decreases blackhead formation.

Do NOT use Differin Lotion if:

• you are allergic to any ingredient in Differin Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Differin Lotion:

Some medical conditions may interact with Differin Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have eczema or sunburn

Some MEDICINES MAY INTERACT with Differin Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Products that contain resorcinol, salicylic acid, or sulfur because the risk of skin irritation may be increased

Ask your health care provider if Differin Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Differin Lotion:

Use Differin Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Differin Lotion is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Differin Lotion to the eye may cause swelling, redness, and irritation.


• Do not apply Differin Lotion to cuts, damaged or sunburned skin, or eczema.


• Use Differin Lotion in the evening before bedtime unless directed otherwise by your doctor.


• Before applying Differin Lotion, clean the area to be treated with mild soap or soapless cleanser and gently dry.


• Apply a thin film of Differin Lotion to the entire face and other affected areas, as directed by your doctor. Use an amount about the size of a nickel (3 to 4 pumps) to cover the entire face. Rub in gently. Wash your hands immediately after using Differin Lotion.


• A mild sensation of warmth or slight stinging may occur shortly after using Differin Lotion.


• If you miss a dose of Differin Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Differin Lotion.

Important safety information:

• Differin Lotion may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Differin Lotion. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Do not use more than the recommended dose or more often than prescribed without checking with your doctor. Doing so will not make Differin Lotion work faster or better, but may increase the risk of skin irritation.


• Acne may worsen temporarily when you begin using Differin Lotion. This is normal and not a cause for concern. Continue to use Differin Lotion. If your condition does not improve within 12 weeks, check with your doctor.


• Do not use other medicines or skin products on the affected area without first checking with your doctor. Some other products may increase the risk of skin irritation.


• Skin moisturizers may be used if necessary. Do not use moisturizers that contain alpha hydroxy or glycolic acids.


• Certain cosmetic procedures, such as waxing, should not be performed on treated skin because of possible irritation.


• Cosmetics may be used while using Differin Lotion. After using cosmetics, thoroughly wash and dry the affected area before applying Differin Lotion.


• Wind and cold temperatures can also irritate the affected skin.


• Differin Lotion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Differin Lotion while you are pregnant. It is not known if Differin Lotion is found in breast milk. If you are or will be breast-feeding while you use Differin Lotion, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Differin Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Differin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Differin Lotion may be harmful if swallowed.

Proper storage of Differin Lotion:

Store Differin Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not freeze or refrigerate. Keep Differin Lotion out of the reach of children and away from pets.

General information:

• If you have any questions about Differin Lotion, please talk with your doctor, pharmacist, or other health care provider.


• Differin Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Differin Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Differin resources

• Differin Side Effects (in more detail)
• Differin Use in Pregnancy & Breastfeeding
• Differin Drug Interactions
• Differin Support Group
• 14 Reviews for Differin - Add your own review/rating

Compare Differin with other medications

• Acne

Roxicaina

Roxicaina may be available in the countries listed below.

Ingredient matches for Roxicaina

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Roxicaina in the following countries:

• Peru

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Moladerm

Moladerm may be available in the countries listed below.

Ingredient matches for Moladerm

Miconazole

Miconazole nitrate (a derivative of Miconazole) is reported as an ingredient of Moladerm in the following countries:

• Indonesia

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Ginacol

Ginacol may be available in the countries listed below.

Ingredient matches for Ginacol

Benzydamine

Benzydamine hydrochloride (a derivative of Benzydamine) is reported as an ingredient of Ginacol in the following countries:

• Venezuela

International Drug Name Search

Hydrocortisone Micronised

Hydrocortisone Micronised may be available in the countries listed below.

Ingredient matches for Hydrocortisone Micronised

Hydrocortisone

Hydrocortisone is reported as an ingredient of Hydrocortisone Micronised in the following countries:

• Hong Kong

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Xenbilox

Xenbilox may be available in the countries listed below.

Ingredient matches for Xenbilox

Chenodeoxycholic Acid

Chenodeoxycholic Acid is reported as an ingredient of Xenbilox in the following countries:

• Germany

International Drug Name Search

Hydrocortison Valeant

Hydrocortison Valeant may be available in the countries listed below.

Ingredient matches for Hydrocortison Valeant

Hydrocortisone

Hydrocortisone 21-(sodium succinate) (a derivative of Hydrocortisone) is reported as an ingredient of Hydrocortison Valeant in the following countries:

• Czech Republic


• Slovakia

International Drug Name Search

Fosphenytoin Sodium

Ingredient matches for Fosphenytoin Sodium

Fosphenytoin

Fosphenytoin Sodium (BANM, USAN) is known as Fosphenytoin in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Soludol

Soludol may be available in the countries listed below.

Ingredient matches for Soludol

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Soludol in the following countries:

• Bangladesh


• Sri Lanka

International Drug Name Search

Lidocaine Hydrochloride and Epinephrine

Ingredient matches for Lidocaine Hydrochloride and Epinephrine

Epinephrine

Epinephrine is reported as an ingredient of Lidocaine Hydrochloride and Epinephrine in the following countries:

• Canada


• United States

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Lidocaine Hydrochloride and Epinephrine in the following countries:

• Canada


• United States

International Drug Name Search

Lingin

Lingin may be available in the countries listed below.

Ingredient matches for Lingin

Levocetirizine

Levocetirizine dihydrochloride (a derivative of Levocetirizine) is reported as an ingredient of Lingin in the following countries:

• Bangladesh

International Drug Name Search

Amitriptyline Hydrochloride

UK matches:

• Amitriptyline Hydrochloride 25mg/5ml and 50mg/5ml Oral Solution (SPC)
• Amitriptyline Hydrochloride 25mg/5ml Oral Solution (SPC)
• Amitriptyline Hydrochloride 50mg/5ml Oral Solution (SPC)

Ingredient matches for Amitriptyline Hydrochloride

Amitriptyline

Amitriptyline Hydrochloride (BANM) is known as Amitriptyline in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Simvacol

Simvacol may be available in the countries listed below.

Ingredient matches for Simvacol

Simvastatin

Simvastatin is reported as an ingredient of Simvacol in the following countries:

• Hungary


• Myanmar


• Portugal

International Drug Name Search

Procaïne chlorhydrate Lavoisier

Procaïne chlorhydrate Lavoisier may be available in the countries listed below.

Ingredient matches for Procaïne chlorhydrate Lavoisier

Procaine

Procaine hydrochloride (a derivative of Procaine) is reported as an ingredient of Procaïne chlorhydrate Lavoisier in the following countries:

• France

International Drug Name Search

Méloxicam Sandoz

Méloxicam Sandoz may be available in the countries listed below.

Ingredient matches for Méloxicam Sandoz

Meloxicam

Meloxicam is reported as an ingredient of Méloxicam Sandoz in the following countries:

• France

International Drug Name Search

Civox

Civox may be available in the countries listed below.

Ingredient matches for Civox

Ciprofloxacin

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Civox in the following countries:

• Bangladesh

International Drug Name Search

Metformin AL

Metformin AL may be available in the countries listed below.

Ingredient matches for Metformin AL

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Metformin AL in the following countries:

• Czech Republic


• Germany


• Romania


• Slovakia

International Drug Name Search

Vincasar

Ingredient matches for Vincasar

Vincristine

Vincristine sulfate (a derivative of Vincristine) is reported as an ingredient of Vincasar in the following countries:

• United States

International Drug Name Search

Fentanyl esparma

Fentanyl esparma may be available in the countries listed below.

Ingredient matches for Fentanyl esparma

Fentanyl

Fentanyl is reported as an ingredient of Fentanyl esparma in the following countries:

• Germany

International Drug Name Search

Roxithromycin AL

Roxithromycin AL may be available in the countries listed below.

Ingredient matches for Roxithromycin AL

Roxithromycin

Roxithromycin is reported as an ingredient of Roxithromycin AL in the following countries:

• Czech Republic


• Germany


• Romania

International Drug Name Search

Ezy

Ezy may be available in the countries listed below.

Ingredient matches for Ezy

Celecoxib

Celecoxib is reported as an ingredient of Ezy in the following countries:

• Bangladesh

International Drug Name Search

Ferrofumaraat ratiopharm

Ferrofumaraat ratiopharm may be available in the countries listed below.

Ingredient matches for Ferrofumaraat ratiopharm

Ferrous Fumarate

Ferrous Fumarate is reported as an ingredient of Ferrofumaraat ratiopharm in the following countries:

• Netherlands

International Drug Name Search

Amoxicillin NM Pharma

Amoxicillin NM Pharma may be available in the countries listed below.

Ingredient matches for Amoxicillin NM Pharma

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxicillin NM Pharma in the following countries:

• Iceland

International Drug Name Search

Métopimazine

Métopimazine may be available in the countries listed below.

Ingredient matches for Métopimazine

Metopimazine

Métopimazine (DCF) is also known as Metopimazine (Rec.INN)

International Drug Name Search

Glossary

DCF	Dénomination Commune Française
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Medepine

Medepine may be available in the countries listed below.

Ingredient matches for Medepine

Metoprolol

Metoprolol tartrate (a derivative of Metoprolol) is reported as an ingredient of Medepine in the following countries:

• Japan

International Drug Name Search

Desowen

Generic Name: desonide (Topical application route)

DES-oh-nide

Commonly used brand name(s)

In the U.S.

• Desonate


• Desowen


• LoKara


• Tridesilon


• Verdeso

In Canada

• Pms-Desonide

Available Dosage Forms:

• Gel/Jelly


• Ointment


• Cream


• Foam


• Lotion

Therapeutic Class: Corticosteroid, Strong

Pharmacologic Class: Adrenal Glucocorticoid

Uses For Desowen

Desonide topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions (e.g., atopic dermatitis). This medicine is a corticosteroid (cortisone-like medicine or steroid).

This medicine is available only with your doctor's prescription.

Before Using Desowen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of desonide topical foam or gel in children 3 months of age and older. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully. For the foam and gel forms, safety and efficacy have not been established in infants younger than 3 months of age. The safety and efficacy of desonide topical cream, lotion, and ointment have not been established in children and use is not recommended.

Geriatric

No information is available on the relationship of age to the effects of desonide topical cream, ointment, or lotion in geriatric patients.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of desonide topical foam or gel in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving desonide topical foam or gel.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

Proper Use of desonide

This section provides information on the proper use of a number of products that contain desonide. It may not be specific to Desowen. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

Do not use the topical gel on the groin or underarms unless directed to do so by your doctor, and do not use this form for more than 4 weeks.

To use cream, gel, lotion, or ointment:

• Wash your hands with soap and water before and after using this medicine.


• Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.


• With the lotion, protect the skin from water, clothing, or anything that causes rubbing until the medicine has dried. Also, shake the lotion well before using it.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

To use the foam:

• Wash your hands with soap and water before and after using this medicine.


• Shake the foam well before using it.


• Do not put the foam directly on your face. Turn the can upside down and place a small amount of medicine in your hands. Massage it gently into the affected areas of the face until the medicine has dried. For areas other than the face, you may put it directly on the affected area.


• Do not wash or rinse the treated area right after applying the medicine.


• Do not use this medicine near heat, an open flame, or while smoking.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For atopic dermatitis:
  
  • For topical dosage forms (foam or gel):
    
    • Adults and teenagers—Apply to the affected area of the skin two times per day.
    
    
    • Children 3 months of age and older—Apply to the affected area of the skin two times per day.
    
    
    • Children younger than 3 months of age—Use and dose must be determined by your doctor.
    
    
  
  


• For redness, itching, and swelling of the skin:
  
  • For topical dosage forms (cream, ointment, or lotion):
    
    • Adults—Apply to the affected area of the skin two or three times per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the foam can at room temperature, away from heat and direct light. Do not keep this medicine inside a car where it could be exposed to extreme heat. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Precautions While Using Desowen

It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by this medicine.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Make sure your doctor knows that you are using desonide foam. You may need to stop using this medicine several days before having surgery.

Do not use cosmetics or other skin care products on the treated areas.

Desowen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Blistering, burning, crusting, dryness, or flaking of the skin


• burning, itching, redness, skin rash, swelling, or soreness at the application site


• flushing or redness of the skin


• irritation


• itching, scaling, severe redness, soreness, or swelling of the skin


• peeling of the skin


• raised, dark red, wart-like spots on the skin, especially when used on the face


• stinging and burning


• unusually warm skin

Incidence not known

• Redness and scaling around the mouth


• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g., between the fingers)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Body aches or pain


• chills


• cough


• difficulty with breathing


• ear congestion


• fever


• headache


• loss of voice


• nasal congestion


• runny nose


• sneezing


• sore throat


• unusual tiredness or weakness

Less common

• Cold flu-like symptoms


• congestion


• cough


• hoarseness


• irritability


• noisy breathing


• shortness of breath


• tender, swollen glands in the neck


• tightness in the chest


• trouble with swallowing


• voice changes


• wheezing

Incidence not known

• Acne or pimples


• burning and itching of the skin with pinhead-sized red blisters


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• lightening of normal skin color


• lightening of treated areas of dark skin


• reddish purple lines on the arms, face, legs, trunk, or groin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Desowen side effects (in more detail)

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More Desowen resources

• Desowen Side Effects (in more detail)
• Desowen Use in Pregnancy & Breastfeeding
• Desowen Drug Interactions
• Desowen Support Group
• 5 Reviews for Desowen - Add your own review/rating

• Desowen Prescribing Information (FDA)


• DesOwen Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• DesOwen Cream Kit Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Desonate Consumer Overview


• Desonate Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Desonate Prescribing Information (FDA)


• LoKara Prescribing Information (FDA)


• LoKara Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Verdeso Prescribing Information (FDA)


• Verdeso Consumer Overview


• Verdeso Foam MedFacts Consumer Leaflet (Wolters Kluwer)

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Ingredient matches for Lysopadol

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Lysopadol in the following countries:

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International Drug Name Search